承担项目（主持） [1] 国家自然科学基金面上项目，多通道荧光/光声成像探针用于肾纤维化分级诊断与中药药效定量评价，2026-2029； [2] 国家自然科学基金面上项目，糖类受体靶向性近红外荧光探针的构建及在炎症性肠病成像中的应用研究，2022-2025； [3] 国家自然科学基金面上项目，基于缺氧诱导释放的近红外诊疗探针的构建及其初步生物医学应用研究，2018-2021； [4] 国家自然科学基金青年项目，基于能量转移机理的蛋白激酶比率荧光分子探针的设计合成及生物医学应用，2011-2013； [5] 湖南省自然科学基金项目面上项目，双模态成像探针的构建及在炎症性肠病早期诊断中的应用研究，2021-2023； [6] 湖南省自然科学基金项目青年人才培养基金，定位线粒体的比率型三磷酸腺苷荧光探针的研究，2015-2017； [7] 湖南省自然科学基金项目面上项目，能量转移型蛋白激酶荧光探针的研究，2011-2013； [8] 中国博士后科学基金特别资助项目，定位线粒体的比率型荧光探针的研究，2015-2016； [9] 中国博士后科学基金面上项目，能量转移型荧光探针的研究，2014-2016； [10] 湖南省教育厅重点项目，缺氧诊疗荧光探针的研究，2019-2021； [11] 湖南省教育厅优秀青年项目，用于三磷酸腺苷定位和检测的双功能比率荧光探针的构建及细胞成像研究，2016-2018。
近5年发表论文（通讯作者） [1] Triple-synergistic mitochondria-targeted NIR fluorescent probe for mitochondrial hydrogen sulfide: precision monitoring and image guided resection of metastatic breast cancer. Analytical Chemistry, 2025, 97, 22318-22329. (自然指数期刊) [2] Zero-crosstalk tumor-targeting ratiometric near-infrared γ-glutamyltranspeptidase probe for fluorescent-guided surgical resection of orthotopic hepatic tumor. Analytical Chemistry, 2025, 97, 185-193. (自然指数期刊) [3] A dual-mode viscosity-activatable probe for immediate evaluation of photodynamic/photothermal therapy efficacy. Chemical Communications, 2025, https://doi.org/10.1039/D5CC06006K. (自然指数期刊) [4] Monitoring the level of hydrogen sulfide in arthritis and its treatment with a novel near-infrared fluorescent probe. Analytica Chimica Acta, 2025, 1351, 343898. [5] Novel near-infrared solid-state probe for monitoring carbon monoxide in cholestatic liver injury and toxic hepatitis. Journal of Materials Chemistry B, 2025, 13, 10893-10902. [6] ATP-responsive nanoparticles for improved chemodynamic therapy and dual starvation therapy. Nanoscale, 2025, 17, 15804-15814. [7] A novel near-infrared fluorescent probe with large Stokes shift for monitoring γ-glutamyltranspeptidase in tumor and liver injury mice. Microchemical Journal, 2025, 209, 112668. [8] A hepatocyte-targeting ratiometric fluorescence probe for monitoring peroxynitrite in liver injury. Microchemical Journal, 2025, 208, 112566. [9] A novel colon-targeting ratiometric probe with large emission shift for imaging peroxynitrite in ulcerative colitis. Analytical Chemistry, 2024, 96, 18852-18858. (自然指数期刊) [10] A near-infrared fluorescent probe for imaging peroxynitrite levels in paw edema mice and drug evaluation. Chemical Communications, 2024, 60, 6675-6678. (自然指数期刊) [11] An intestinal-targeting near-infrared probe for imaging nitroreductase in inflammatory bowel disease. Sensors and Actuators: B. Chemical, 2024, 403, 135181. [12] ATP-responsive copper(II)-doped ZIF-nanoparticles for synergistic cancer therapy: combining cuproptosis and chemo/chemodynamic therapy. Journal of Materials Chemistry B, 2024, 12, 11414-11425. [13] An ATP-responsive ZIF-based NIR fluorescence nanosystem for enhanced chemo-photodynamic therapy of tumors. Nanoscale, 2024, 16, 20617-20627. [14] Glutathione-activated biotin-targeted dual-modal imaging probe with improved PDT/PTT synergistic therapy. Analytica Chimica Acta, 2024, 1316, 342860. [15] A near-infrared fluorescent probe for viscosity: Differentiating cancer cells from normal cells and dual-modal imaging in tumor mice. Analytica Chimica Acta, 2024, 1285, 342024. [16] Near-infrared fluorescent probe for the imaging of viscosity in fatty liver mice and valuation of drug efficacy. Talanta, 2024, 276, 126227. [17] A dual-response fluorescent probe for detecting sulfur dioxide and hypochlorous acid in cells, water and food. Microchemical Journal, 2024, 205, 111171. [18] A tumor-targeting dual-modal imaging probe for nitroreductase in vivo. Bioorganic Chemistry, 2024, 149, 107531. [19] Long-term imaging of Cys in cells and tumor mice by a solid-state fluorescence probe. Analytical Chemistry, 2023, 95, 17559-17567. (自然指数期刊) [20] Tumor-targeting probe for dual-modal imaging of cysteine in vivo. Analytical Chemistry, 2023, 95, 12478-12486. (自然指数期刊) [21] Near-infrared fluorescent nanoprobes for adenosine triphosphate guided imaging in cancer and fatty liver mice, Analytical Chemistry, 2023, 95, 2119-2127. (自然指数期刊) [22] A novel near-infrared fluorescent probe for the imaging of viscosity in cells and tumor-bearing mice. Chemical Communications, 2023, 59, 5607-5610. (自然指数期刊) [23] Dual key-activated NIR-I/II fluorescence probe for monitoring photodynamic and photothermal synergistic therapy efficacy. Advanced Healthcare Materials, 2023, 12, 2301230. [24] A tumor-targeting fluorescent probe for ratiometric imaging of pH and improving PDT/PTT synergistic therapy. Sensors and Actuators: B. Chemical, 2023, 393, 134287. [25] A near-infrared fluorescent probe for monitoring abnormal mitochondrial viscosity in cancer and fatty-liver mice model. Analytica Chimica Acta, 2023, 1242, 340813. [26] A dual-channel fluorescent nanoprobe for accurate cancer diagnosis by sequential detection of adenosine triphosphate and sulfur dioxide. Talanta, 2023, 265, 124815. [27] A near-infrared fluorescent probe for detecting hydrogen sulfide with high selectivity in cells and ulcerative colitis in mice. Analyst, 2023, 148, 5724-5730. [28] Recent advances in design strategies and imaging applications of fluorescent probes for ATP. Chemosensors, 2023, 11, 417. [29] Near-infrared fluorescent probe with large stokes shift for imaging of hydrogen sulfide in tumor-bearing mice, Analytical Chemistry, 2022, 94, 5514-5520. (自然指数期刊) [30] A dual-channel fluorescent nanoprobe for sequential detection of ATP and peroxynitrite to accurately distinguish between normal cells and cancer cells, Analytical Chemistry, 2022, 94, 14257-14264. (自然指数期刊) [31] ATP fluorescent nanoprobe based on ZIF-90 and near-infrared dyes for imaging in tumor mice, Sensors & Actuators: B. Chemical, 2022, 369, 132286. [32] ATP-responsive near-infrared fluorescent nanoparticles for synergistic chemotherapy and starvation therapy, Nanoscale, 2022, 14, 3808-3817. [33] A dual-response fluorescent probe for simultaneously monitoring polarity and ATP during autophagy, Journal of Materials Chemistry B, 2022, 10, 4285-4292. [34] A tumor-targeting near-infrared fluorescent probe for real-time imaging ATP in cancer cells and mice, Analytica Chimica Acta, 2022, 1206, 339798. [35] A HPQ-based far-red fluorescent probe for monitoring viscosity in mice model of acute inflammation, Analytica Chimica Acta, 2022, 1226, 340192. [36] A novel precipitating-fluorochrome-based fluorescent probe for monitoring carbon monoxide during drug-induced liver injury, Talanta, 2022, 243, 123398. [37] A nitrobenzoxadiazole-based near-infrared fluorescent probe for the specific imaging of H2S in inflammatory and tumor mice, Analyst, 2022, 147, 2712-2717. [38] A tumor-targeting and polarity-specific near-infrared fluorescent probe for accurate cancer diagnosis in vivo, Dyes and Pigments, 2022, 206, 110612. [39] Accurate fluorescence diagnosis of cancer based on sequential detection of hydrogen sulfide and pH, Analytical Chemistry, 2021, 93, 11826-11835. (自然指数期刊) [40] Monitoring the fluctuation of hydrogen peroxide in diabetes and its complications with a novel near-infrared fluorescent probe, Analytical Chemistry, 2021, 93, 3301-3307. (自然指数期刊) [41] Construction of NIR and ratiometric fluorescent probe for monitoring carbon monoxide under oxidative stress in zebrafish, Analytical Chemistry, 2021, 93, 2510-2518. (自然指数期刊) [42] A novel near-infrared theranostic probe for accurate cancer chemotherapy in vivo by a dual activation strategy, Chemical Communications, 2021, 57, 13768-13771. (自然指数期刊) [43] A near-infrared fluorescent probe for accurately diagnosing cancer by sequential detection of cysteine and H+, Chemical Communications, 2021, 57, 4811-4814. (自然指数期刊) [44] Real-time imaging of alkaline phosphatase activity of diabetes in mice via a near-infrared fluorescent probe, Chemical Communications, 2021, 57, 480-483. (自然指数期刊) [45] NAD(P)H-triggered probe for dual-modal imaging during energy metabolism and novel strategy of enhanced photothermal therapy in tumor, Biomaterials, 2021, 271, 120736. [46] A novel HPQ-based fluorescent probe for the visualization of carbon monoxide in zebrafish, Sensors and Actuators B: Chemical, 2021, 340, 129920. [47] A near-infrared fluorescent probe with large Stokes shift for imaging Cys in tumor mice, Analytica Chimica Acta, 2021, 1171, 338655. [48] Novel near-infrared fluorescence probe with large Stokes shift for monitoring CCl4-induced toxic hepatitis, Talanta, 2021, 223, 121720. [49] ATP-responsive near-infrared fluorescence MOF nanoprobe for the controlled release of anticancer drug. Microchimica Acta, 2021, 188, 287. [50] The construction of a near-infrared fluorescent probe with dual advantages for imaging carbon monoxide in cells and in vivo. Analyst, 2021, 146, 118-123.
近3年授权专利 [1] 基于花菁染料的靶向性谷胱甘肽荧光探针的制备和应用，专利号ZL2023105324434. [2] 一种检测微囊藻毒素-LR的荧光探针的制备和应用，专利号ZL2022109545501. [3] 一种靶向性硝基还原酶荧光探针的制备和应用，专利号ZL2023104018060. [4] 一种基于吡喃-香豆素的肼荧光探针的制备和应用，专利号ZL2023103052914. [5] 一种靶向性过氧亚硝基荧光探针的制备和应用，专利号ZL2022108738206. [6] 一种基于异氟尔酮-氧杂蒽的粘度荧光探针的制备和应用，专利号ZL2023103963838. [7] 基于噻吩-氧杂蒽染料的硫化氢荧光探针的制备和应用，专利号ZL2022107967759. [8] 一种基于硅罗丹明的近红外MOF荧光探针的制备和应用，专利号ZL2022102869266. [9] 基于异佛尔酮-肉桂醛的粘度荧光探针的制备和应用，专利号ZL2021108175659. [10] 基于花菁染料的靶向性比率pH荧光探针的制备和应用，专利号ZL2022104956269. [11] 李春艳，刘娟，一种半胱氨酸近红外荧光探针的制备和应用，专利号2020104384010. [12] 基于花菁染料的靶向性半胱氨酸荧光探针的制备和应用，专利号ZL2022103209367.
研究生培养 [1] 在读：王之卿（博士），钞静静（博士），陈静（博士），付翱翔（博士），杨科（博士），陈丽缘，贺培德，邓伟群，刘嘉雨，孙溜，叶明扬，赵慧，曹聪平，徐佳，朱湘锦，刘礼铭，曹力文 [2] 已毕业：江文丽（博士，校长奖特等奖），王文新（博士，国家奖学金，校长奖），杨志超，宋倩，李莉，许小帆，杨志豪，李婷，陈思思，张会，胡玲，秦崇康，侯美家，闫灵，廖沁婷，付贵勤（国家奖学金），顾青松（湖南省优秀硕士学位论文），陈骏涛，刘娟，夏雨桑，佘遵攀（湖南省优秀硕士学位论文），陈茜茜，赵仪婷，田杨（校长奖，湖南省优秀硕士学位论文），张烁，周东叶，欧阳娟（国家奖学金，校长奖特等奖，湖南省优秀硕士学位论文），李宋娇（国家奖学金），谢俊英（国家奖学金，校长奖），谭凯月，付雅俊，吴银双（国家奖学金），李丹，李芝，唐佳良（国家奖学金），卢曦，邹春香（国家奖学金），孔雪飞（校长奖），周雨（校长奖），徐芬（校长奖）
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