科研项目 1. 湖南省自然科学基金青年项目，2021JJ40532，PERK/elF2α/CHOP通路在氟虫腈致L02肝细胞损失中的分子机制研究，2021/01-2023/12，结题，主持 2.湘潭大学自然科学基金，15XZX18，热敏聚合物对人脐静脉内皮细胞生物相容性研究，2016/01-2017/12，结题，主持
3.湖南省教育厅科学研究项目，15C1331，自由基介导的维格列汀引起人肾小管上皮细胞损伤的机制研究，2015/09-2017/12，结题，主持
4.湘潭大学科研启动基金，15QDZ14，DPP-4抑制剂维格列汀致人肾小管上皮细胞株(HK-2)损伤的分子机理，2015/01-2017/12，结题，主持
5.国家自然科学基金面上项目，31272614，喹噁啉类化合物肾上腺毒性机制的研究，2013/01-2016/12，结题，参加 5. 湖南省自然科学基金青年项目，2021JJ40532，PERK/elF2α/CHOP通路在氟虫腈致L02肝细胞损失中的分子机制研究，2021.01-2023.12，结题，主持 发表论文 1.Yingmei Luo; Juan Li; Chaobo Huang; Xuefeng Wang; Dingxin Long; Yi Cao ; Graphene oxide links alterations of anti-viral signaling pathways with lipid metabolism via suppressing TLR3 in vascular smooth muscle cells, Molecular omics, 2022, 18(8): 779-790 2.Jiaoqin Shou; Mi Wang; Xiaolei Cheng; Xiaoyang Wang; Lifang Zhang; Yingchun Liu; Chenzhong Fei; Chunmei Wang; Feng Gu; Feiqun Xue; Juan Li; Keyu Zhang ; Tizoxanide induces autophagy by inhibiting PI3K/Akt/mTOR pathway in RAW264.7 macrophage cells, Archives of Pharmacal Research, 2020, 43: 257-270 3.Chunxue Zhao; Yiwei Zhou; Liangliang Liu; Jimin Long; Hongwen Liu; Juan Li; Yi Cao; Lipid accumulation in multi-walled carbon nanotube-exposed HepG2 cells: Possible role of lipophagy pathway, Food and Chemical Toxicology, 2018, 121(1): 65-71 4.Yu Gong; Xianqiang Li; Guochao Liao; Yanhuai Ding; Juan Li; Yi Cao ; Cytotoxicity and ER stress-apoptosis gene expression in ZnO nanoparticle exposed THP-1 macrophages: influence of pre-incubation with BSA or palmitic acids complexed to BSA, RSC Advances, 2018, 8: 15380 5. Yu Gong; Liangliang Liu; Juan Li; Yi Cao; The presence of palmitate affected the colloidal stability of ZnO NPs but not the toxicity to Caco-2 cells, Journal of Nanoparticle Research, 2017, 19: 335. 6.Xianqiang Li ; Xin Fang; Yanhuai Ding; Juan Li ; Yi Cao,Toxicity of ZnO nanoparticles (NPs) with or without hydrophobic surface coating to THP-1 macrophages: interactions with BSA or oleate-BSA., Toxicology Mechanisms and Methods, 2018, 28 (7): 520~528 7. Yuejia Ji, Mengxiang Zhu, Yu Gong, Haoyu Tang, Juan Li, Yi Cao, Thermoresponsive Polymers with Lower Critical Solution Temperature- or Upper Critical Solution Temperature-Type Phase Behaviour Do Not Induce Toxicity to Human Endothelial Cells, Basic & Clinical Pharmacology & Toxicology, in press （DOI: 10.1111/bcpt.12643）.
8. Yu Gong, Yuejia Ji, Fang Liu, Juan Li, Yi Cao. Cytotoxicity, oxidative stress and inflammation induced by ZnO nanoparticles in endothelial cells: interaction with palmitate or lipopolysaccharide. Journal of Applied Toxicology, in press
9. Juan Li, Lingli Huang, Xu Wang, Yuanhu Pan, Zhaoying Liu, Dongmei Chen, Yanfei Tao, Zonghui Yuan, Metabolic disposition and excretion of quinocetone in rats, pigs, broilers, and carp. Food and Chemical Toxicology. 2014, 69, 109-119.
10. Juan Li, Lingli Huang, Yuanhu Pan, Dongmei Chen, Xu Wang, Ijaz Ahmad, Yanfei Tao, Zhenli Liu, Zonghui Yuan. Tissue depletion of quinocetone and its five major metabolites in pigs, broilers and carp fed quinocetone premix. Journal of Agricultural and Food Chemistry. 2014, 62, 10348-10356.
11. Yi Cao, Juan Li, Fang Liu, Xiyue Li, Qin Jiang, Shanshan Cheng, Yuxiu Gu, Consideration of interaction between nanoparticles and food components for the safety assessment of nanoparticles following oral exposure: A review, environmental toxicology and pharmacology, doi: 10.1016/j.etap.2016.07.023, 2016.
12. Yi Cao, Jimin Long, Yuejia Ji, Gui Chen, Yuexin Shen, Yu Gong & Juan Li. Foam cell formation by particulate matter (PM) exposure: a review. Inhalation Toxicology, 2016, 28(13): 583-590.
13. Qinghua Wu, Xu Wang, Dan Wan, Juan Li, Zonghui Yuan. Crosstalk of JNK1-STAT3 is critical for RAW264.7 cell survival. Cellular Signalling. 2014, 26, 2951-2960.
14. Xu Wang, Huahai Zhang, Lingli Huang, Yuanhu Pan, Juan Li, Dongmei Chen, Guyue Cheng, Haihong Hao, Yanfei Tao, Zhenli Liu, Zonghui Yuan. Deoxidation rates play critical role in DNA damage of important synthetic drugs, quinoxaline 1,4-dioxides. Chemical Research in Toxicology.2015, 28(3):470-481.
15. Lingli Huang, Fujun Yin, Yuanhu Pan, Dongmei Chen, Juan Li, Dan Wan, Zhenli Liu, Zonghui Yuan. Metabolism, Distribution, and Elimination of Mequindox in Pigs, Chickens, and Rats. Journal of Agricultural and Food Chemistry. 2015, 63(44), 9839-9849.
16. Xu Wang, Dan Wan, Awais Ihsan, Qianying Liu, Guyue Cheng, Juan Li, Zhenli Liu, Zonghui Yuan. Mechanism of adrenocortical toxicity induced by quinocetone and its bidesoxy-quinocetone metabolite in porcine adrenocortical cells in vitro. Food and Chemical Toxicology. 2015, 84, 115-124.
17. Ijaz Ahmad, Haihong Hao, Lingli Huang, Pascal Sanders, Xu Wang, Dongmei Chen, Yanfei Tao, Shuyu Xie, Xiuhua Kuang, Juan Li, Dan Wan, Zonghui Yuan. Integration of PK/PD for dose optimization of Cefquinome against Staphylococcus aureuscausing septicemia in cattle. Frontiers in Microbiology 6:588. doi: 10.3389/fmicb.2015.00588.
18. Dan Wan, Lingli Huang, Yuanhu Pan,Qinghua Wu, Dongmei Chen, Yanfei Tao, Xu Wang, Zhenli Liu, Juan Li, Liye Wang and Zonghui Yuan. Metabolism, distribution, and excretion of deoxynivalenol with combined techniques of radiotracing, high-performance liquid chromatography ion trap time-of-flight mass spectrometry, and online radiometric detection. Journal of Agricultural and Food Chemistry. 2014, 62 (1), 288-296.
19. Juan Li, Lingli Huang, Dongmei Chen, Yuanhu Pan, Yanfei Tao, Zonghui Yuan. Disposition of [3H]quinocetone in rats following oral administration. The Second Sino-UK International Meeting on Animal Production and Disease Control & Doctoral Students Forum on Veterinary Medicine, P31. 2011.10.
20. Min Yao, Menghong Dai, Zhaoying Liu, Wenlong Cui, Daoyuan Li, Huahai Zhang, Juan Li, Yahui Liu, Zonghui Yuan. mRNA expression profiles of P450 3A enzymes in the liver and small intestine of the domestic pig. Research in Veterinary Science. 2012, 93(1), 360-365. 荣誉奖励 1. 指导顾毓秀同学获得“第九届湖南省大学生课外化学化工创新作品竞赛”一等奖，2017.05 2. 指导顾毓秀同学获得“湖南省第七届大学生化学化工实验与创新设计竞赛”一等奖，2017.07 3. 指导周逸威同学获得“第十届湖南省大学生课外化学化工创新作品竞赛”一等奖，2018.07 4. 指导肖倩等同学获得“第三届湖南省大学生虚拟仿真竞赛”一等奖，2023.06 5. 指导肖倩等同学获得“第十三届湖南省大学生化学化工学科竞赛（虚拟仿真）”二等奖，2023.07 6. 2017-2018年度和2021-2022年度获得“优秀班主任” 7. 2019年度湘潭大学获“嘉奖” |