欧阳娟

职称：副教授

性别：女

职务：

办公电话：

移动电话：

家庭电话：

家庭住址：

电子邮箱：oyj2023@xtu.edu.cn

工作学习经历

主讲课程

《分析化学》、《分析化学实验》

研究方向

功能光学材料（包括荧光、光声、化学发光和长余辉发光探针，以及智能纳米材料）的设计、合成及应用

主要学术成果

一、科研项目：

[1] 国家自然科学基金-青年基金项目，2025-2027年，主持

[2] 中国博士后科学基金第76批面上资助，2024-2026年，主持

[3] 湖南省自然科学基金-青年基金项目，2024-2026年，主持

[4] 广东省自然科学基金面上项目，2024-2026年，主持

[5] 湘潭大学人才引进科研启动项目，2023-2029年，主持

[6] 中国博士后科学基金第72批面上资助，2023年，主持

[7] 湖南省研究生科研创新项目，2017-2019年，主持

二、学术论文：

2025年

[1] Zhi-Hao Yang, Zhi-Chao Yang, Jiang-Tao Zhao, Ao-Xiang Fu, Guo-Jiang Mao, Liufang Hu, Juan Ouyang*, and Chun-Yan Li*, Triple-synergistic mitochondria-targeted NIR fluorescent probe for mitochondrial hydrogen sulfide: Precision monitoring and image-guided resection of metastatic breast cancer. Analytical Chemistry, 2025, 97, 22318-22329. (通讯作者，IF = 6.7)

[2] Zhi-Chao Yang, Zhi-Hao Yang, Zhi-Qing Wang, Yao Li, Guo-Jiang Mao, Liufang Hu, Juan Ouyang*, and Chun-Yan Li*, Zero-crosstalk tumor-targeting ratiometric near-infrared γ-glutamyltranspeptidase probe for fluorescent-guided surgical resection of orthotopic hepatic tumor. Analytical Chemistry, 2025, 97, 185-193. (通讯作者，IF = 6.7)

[3] Jing-Jing Chao, Ling Hu, Jing-Fang Mi, Guo-Jiang Mao, Fen Xu, Liufang Hu, Juan Ouyang*, and Chun-Yan Li*, Monitoring the level of hydrogen sulfide in arthritis and its treatment with a novel near-infrared fluorescent probe. Analytica Chimica Acta, 2025, 1351, 343898. (通讯作者，IF = 6.0)

[4] Xiao-Fan Xu, Jun-Tao Chen, Qian Song, Zhi-Qing Wang, Jia-Qin Long, Guo-Jiang Mao, Yongfei Li, Liufang Hu, Juan Ouyang*, and Chun-Yan Li*, ATP-responsive nanoparticles for improved chemodynamic therapy and dual starvation therapy. Nanoscale, 2025, 17, 15804. (通讯作者，IF = 5.1)

2024年

[1] Wei-Qun Deng, Jun-Tao Chen, Si-Si Chen, Zhi-Qing Wang, Guo-Jiang Mao, Liufang Hu, Juan Ouyang*, and Chun-Yan Li*, ATP-responsive copper(II)-doped ZIF-nanoparticles for synergistic cancer therapy: combining cuproptosis and chemo/chemodynamic therapy. Journal of Materials Chemistry B, 2024, 12, 11414. (通讯作者，IF = 5.7)

[2] Si-Si Chen, Xiao-Fan Xu, Wei-Qun Deng, Guo-Jiang Mao, Liufang Hu, Juan Ouyang*, and Chun-Yan Li*, An ATP-responsive ZIF-based NIR fluorescence nanosystem for enhanced chemo-photodynamic therapy of tumors. Nanoscale, 2024, 16, 20617. (通讯作者，IF = 5.1)

[3] Zhi-Chao Yang, Qing-Song Gu, Jing-Jing Chao, Fang-Yuan Tan, Guo-Jiang Mao, Liufang Hu, Juan Ouyang*, and Chun-Yan Li*, Glutathione-activated biotin-targeted dual-modal imaging probe with improved PDT/PTT synergistic therapy. Analytica Chimica Acta, 2024, 1316, 342860. (通讯作者，IF = 6.0)

[4] Juan Ouyang, Lihe Sun, Zunpan She, Rong Li, Fang Zeng*, Zhicheng Yao*, Shuizhu Wu*, Microneedle system with biomarker-activatable chromophore as both optical imaging probe and anti-bacterial agent for combination therapy of bacterial-infected wounds and outcome monitoring. ACS Applied Materials & Interfaces, 2024, 16, 20315-20328. (IF = 8.2)

[5] Lihe Sun^#, Juan Ouyang^#, Zunpan She, Rong Li, Fang Zeng*, Zhicheng Yao*, Shuizhu Wu*, Injectable-hydrogel-based tissue sealant for hemostasis, bacteria inhibition, and pro-angiogenesis in organ bleeding wounds and therapeutic outcome monitoring via NIR-II optical imaging. Advanced Healthcare Materials, 2024, 13, 2303997. (共同一作，IF = 9.6)

2024年以前

[1] Juan Ouyang, Lihe Sun, Zhou Zeng, Cheng Zeng, Fang Zeng*, Shuizhu Wu*, Nanoaggregate probe for breast cancer metastasis through multispectral optoacoustic tomography and aggregation-induced NIR-I/II fluorescence imaging. Angewandte Chemie International Edition, 2020, 59, 10111-10121. (IF = 16.9)；

[2] Juan Ouyang, Lihe Sun, Fang Zeng*, Shuizhu Wu*, Biomarker-activatable probes based on smart AIEgens for fluorescence and optoacoustic imaging. Coordination Chemistry Reviews, 2022, 456, 214438. (IF = 23.5)

[3] Juan Ouyang, Lihe Sun, Jiayue Pan, Zhuo Zeng, Cheng Zeng, Fang Zeng*, Mei Tian*, Shuizhu Wu*, A targeted nanosystem for detection of inflammatory diseases via fluorescent/optoacoustic imaging and therapy via modulating Nrf2/NF-κB pathways. Small, 2021, 17, 2102598. (IF = 12.1)

[4] Lihe Sun^#, Juan Ouyang^#, Fang Zeng*, Shuizhu Wu*, An AIEgen-based oral-administration nanosystem for detection and therapy of ulcerative colitis via 3D-MSOT/NIR-II fluorescent imaging and inhibiting NLRP3 inflammasome. Biomaterials, 2022, 283, 121468. (共同一作，IF = 12.9)

[5] Lihe Sun^#, Juan Ouyang^#, Zhuo Zeng, Cheng Zeng, Yunqing Ma, Fang Zeng*, Shuizhu Wu*, Targeted and activatable nanosystem for fluorescent and optoacoustic imaging of immune-mediated inflammatory diseases and therapy via inhibiting NF-κB/NLRP3 pathways. Bioactive Materials, 2022, 10, 79-92. (共同一作，IF = 20.3)

[6] Juan Ouyang, Lihe Sun, Fang Zeng*, Shuizhu Wu*, Rational design of stable heptamethine cyanines and development of a biomarker-activatable probe for detecting acute lung/kidney injuries via NIR-II fluorescence imaging. Analyst, 2022, 147, 410-416. (IF = 3.3)

[7] Lihe Sun^#, Juan Ouyang^#, Yunqing Ma, Zhuo Zeng, Cheng Zeng, Fang Zeng*, Shuizhu Wu*, An activatable probe with aggregation-induced emission for detecting and imaging herbal medicine induced liver injury with optoacoustic imaging and NIR-II fluorescence imaging. Advanced Healthcare Materials, 2021, 10, 2100867. (共同一作，IF = 9.6)

[8] Zhou Zeng^#, Juan Ouyang^#, Lihe Sun, Cheng Zeng, Fang Zeng*, Shuizhu Wu*, Activatable nanocomposite probe for preoperative location and intraoperative navigation for orthotopic hepatic tumor resection via MSOT and aggregation-induced near-IR-I/II fluorescence imaging. Analytical Chemistry, 2020, 92, 9257-9664. (共同一作，IF = 6.7)

[9] Juan Ou-Yang, Yongfei Li, Wen-Li Jiang, Shuang-Yan He, Hong-Wen Liu*, Chun-Yan Li*, Fluorescence-guided cancer diagnosis and surgery by a zero cross-talk ratiometric near-infrared γ‑glutamyltranspeptidase fluorescent probe. Analytical Chemistry, 2019, 91, 1056-1063. (IF = 6.7)

[10] Juan Ou-Yang, Yongfei Li, Ping Wu, Wen-Li Jiang, Hong-Wen Liu*, Chun-Yan Li*, Detecting and imaging of γ‑glutamytranspeptidase activity in serum, live cells, and pathological tissues with a high signal-stability probe by releasing a precipitating fluorochrome. ACS Sensors, 2018, 3, 1354-1361. (IF = 9.1)

[11] Juan Ou-Yang, Wen-Li Jiang, Kai-Yue Tan, Hong-Wen Liu, Song-Jiao Li, Juan Liu, Yongfei Li, Chun-Yan Li*, Two-photon fluorescence probe for precisely detecting endogenous H₂S in lysosome by employing a dual lock system. Sensors and Actuators B: Chemical, 2018, 260, 264-273. (IF = 7.7)

[12] Juan Ou-Yang, Chun-Yan Li*, Yongfei Li, Bin Yang, Song-Jiao Li, An infinite coordination polymer nanoparticles-based near-infrared fluorescent probe with high photostability for endogenous alkaline phosphatase in vivo. Sensors and Actuators B: Chemical, 2018, 255, 3355-3363. (IF = 7.7)

[13] Juan Ou-Yang, Chun-Yan Li*, Yongfei Li, Junjie Fei, Fen Xu, Song-Jiao Li, Shi-Xin Nie, A rhodamine-based fluorescent probe with high water solubility and its application in the detection of glutathione with unique specificity. Sensors and Actuators B: Chemical, 2017, 240, 1165-1173. (IF = 7.7)

[14] Zhi Li^#, Juan Ou-Yang^#, Ya-Jun Fu, Chun-Yan Li*, Yongfei Li, Song-Jiao Li, A borondipyrrolemethene-based turn-on fluorescent probe for silver ion with high sensitivity and selectivity and its application in water samples and living cells. Tetrahedron Letters, 2017, 58, 3536-3540. (共同一作，IF = 1.5)

三、授权专利：

[1] 基于罗丹明的GSH水溶性荧光探针的制备方法和应用，专利号ZL201610821181.3；

个人简介

欧阳娟，女，湖南株洲人，中共党员。现为湘潭大学化学学院副教授。硕士毕业于湘潭大学，师从李春艳教授；博士毕业于华南理工大学，师从吴水珠教授；随后留校继续博士后研究，合作导师为曾钫教授和吴水珠教授；2024年在湖南大学从事博士后研究，合作导师为张晓兵教授。主要从事分子光学探针设计合成、多功能纳米诊疗体系的构建及其在传感、检测、成像、诊断与治疗等领域的应用研究。在Coordination Chemistry Reviews, Angewandte Chemie International Edition, Small, Biomaterials, Bioactive Materials, Analytical Chemistry等国际著名期刊上发表论文43篇（其中第一作者或共同第一作者论文16篇，通讯作者文章7篇）；获国家授权发明专利1项。主持科研项目7项，包括国家自然科学基金-青年基金项目、中国博士后科学基金面上资助项目、湖南省自然科学基金-青年基金项目、广东省自然科学基金-面上项目、湖南省研究生科研创新项目和湘潭大学人才引进科研启动项目等，并参与多项国家自然科学基金-面上项目。曾获“湖南省优秀硕士学位论文”、“博士研究生国家奖学金”、“华南理工大学校长奖学金”、“湘潭市自然科学优秀学术论文一等奖”、“湘潭大学特等校长奖学金”和“硕士研究生国家奖学金”、“湘潭大学优秀班主任”等荣誉。

学术主页：https://www.researchgate.net/profile/Juan-Ouyang-4/publications 

欢迎大家踊跃报考课题组研究生，一起探索功能光学材料的奥秘！

同时欢迎有兴趣的本科生进实验室学习！